This handbook provides information to ensure ethical conduct of research at Pathways, emphasizing the importance of respecting participants' rights and dignity throughout the process. These guidelines cover critical aspects such as planning, working with an IRB, recruiting and training collaborators, recruiting participants, data collection and analysis, presentation, the storage and deletion of sensitive data, and closing out a project. By consistently following these principles, Pathways Research can foster trust, protect participants' rights, and promote ethical conduct, ensuring that our work is respectful, transparent, and considerate of the communities involved.